A polyunsaturated fatty acid; found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid; reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner; induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA in vitro; decreases Bcl-2 protein expression and induces apoptosis in T24 bladder cancer cells via production of ROS; inhibits bacterial fatty acid dioxygenase (Ki = 49 nM)

9(E),11(E),13(E)-Octadecatrienoic Acid – 1 mg

Brand:
Cayman
CAS:
544-73-0
Storage:
-20
UN-No:
Non-Hazardous - /

9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid.{37085} It reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner. In vitro, β-ESA induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA. β-ESA decreases protein expression of the apoptosis suppression factor Bcl-2 and induces apoptosis in T24 bladder cancer cells via production of reactive oxygen species.{37086} It also inhibits bacterial fatty acid dioxygenase with a Ki value of 49 nM in vitro.{37087}  

 

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Description

A polyunsaturated fatty acid; found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid; reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner; induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA in vitro; decreases Bcl-2 protein expression and induces apoptosis in T24 bladder cancer cells via production of ROS; inhibits bacterial fatty acid dioxygenase (Ki = 49 nM)

Formal name: 9E,11E,13E-octadecatrienoic acid

Synonyms:  β-Eleostearic Acid|β-ESA

Molecular weight: 278.4

CAS: 544-73-0

Purity: ≥97%

Formulation: A solution in methanol

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Tumor Microenvironment||Research Area|Lipid Biochemistry|Fatty Acids

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