An ellipticine derivative with diverse biological activities; inhibits aroclor-induced activation of aniline hydroxylase

9-Hydroxyellipticine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
52238-35-4
Storage:
-20
UN-No:
Non-Hazardous - /

9-Hydroxyellipticine is a derivative of ellipticine (Item No. 18742) with diverse biological activities.{45370,45371,45372} It inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively).{45370} 9-Hydroxyellipticine inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model.{45371,45372} It inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs.{45373}  

 

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Description

An ellipticine derivative with diverse biological activities; inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively); inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model; inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs

Formal name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol, monohydrochloride

Synonyms:  9-OH-Ellipticine|NSC 210717

Molecular weight: 298.8

CAS: 52238-35-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation

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