8-iso PGF2β is an isomer of PGF2α with a non-enzymatic

8-iso Prostaglandin F2β – 5 mg

Brand:
Cayman
CAS:
177020-26-7
Storage:
-20
UN-No:
De Minimis - 1231 / 3

8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery{11143} and does not promote aggregation of human whole blood.{11143,11145} However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α{11144,11146}  

 

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Description

8-iso PGF2β is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery{11143} and does not promote aggregation of human whole blood.{11143,11145} However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α{11144,11146}

Formal name: 9β,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid

Synonyms:  8-epi PGF2β|8-iso PGF2β|8-iso-9β-PGF2α

Molecular weight: 354.5

CAS: 177020-26-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Isoprostanes||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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