A quantitative analytical standard guaranteed to meet MaxSpec® identity

8-iso Prostaglandin F2α MaxSpec® Standard – 100 µg

Brand:
Cayman
CAS:
27415-26-5
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It is present in human plasma in two distinct forms – esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.{855} 8-iso Prostaglandin F2α MaxSpec® standard is a quantitative grade standard of 8-iso Prostaglandin F2α (Item No. 16350) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 8-iso Prostaglandin F2α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.  

 

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SKU: 25903 - 100 µg Category:

Description

A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications

Formal name: 9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid

Synonyms:  15-F2t-Isoprostane|8-epi PGF2α|8-iso PGF2α|8-iso-15(S)-Prostaglandin F2α|8-Isoprostane|iPF2α-III

Molecular weight: 354.5

CAS: 27415-26-5

Purity: >95%

Formulation: A solution in ethanol at 100 µg/ml

Product Type|Biochemicals|Analytical Standards|MaxSpec®||Product Type|Biochemicals|Lipids|Isoprostanes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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