A 5-HT1A receptor agonist (EC50 = 12 nM in rat hippocampal membranes); enhances the behavioral effects of Δ9-THC in rhesus monkeys in a discriminant stimulus-shock test (0.178 mg/kg

8-hydroxy DPAT (hydrobromide) – 10 mg

Brand:
Cayman
CAS:
76135-31-4
Storage:
-20
UN-No:
Non-Hazardous - /

8-Hydroxy DPAT (8-OH-DPAT) is an agonist of serotonin (5-HT) receptor subtype 5-HT1A (EC50 = 12 nM in rat hippocampal membranes).{40744} It mimics the effect of serotonin (Item No. 14332) on reducing excitatory post-synaptic potentials (EPSPs) in the entorhinal cortex layers II and III when used at concentrations of 10 and 50 µM.{40748} In rhesus monkeys, it enhances the behavioral effects of Δ9-tetrahydrocannabinol (Δ9-THC; Item Nos. 12068 | ISO60157) in a discriminant stimulus-shock test when administered at a dose of 0.178 mg/kg.{40743} In mice, 8-OH-DPAT reduces the number of attack bites when administered directly to the dorsal raphe nucleus in a baclofen-induced model of aggressiveness and impairs contextual fear when administered prior to training at a dose of 0.5 mg/kg.{40747,40746} It also reduces the incidence of apnea and improves respiratory regularity in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome when administered at a dose of 50 µg/kg.{40742} In a rat model of diabetes, 8-OH-DPAT enhances bradycardia in response to vagal electrical stimulation.{40745}  

 

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Description

A 5-HT1A receptor agonist (EC50 = 12 nM in rat hippocampal membranes); enhances the behavioral effects of Δ9-THC in rhesus monkeys in a discriminant stimulus-shock test (0.178 mg/kg, i.v.); reduces baclofen-induced aggression in mice when administered directly to the dorsal raphe nucleus; impairs contextual fear in mice when administered prior to training (0.5 mg/kg, s.c); reduces apnea in a methyl-CpG-binding protein 2-deficient mouse model of Rett syndrome (50 µg/kg i.p.)

Formal name: 7-(dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol, monohydrobromide

Synonyms:  8-OH-DPAT

Molecular weight: 328.3

CAS: 76135-31-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Cannabinoid Research

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