A natural chemical that activates TRPV1 (EC50 = 5.0 µM)

8-Gingerol – 1 mg

Brand:
Cayman
CAS:
23513-08-8
Storage:
-20
UN-No:
Non-Hazardous - /

8-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It contains the same aromatic region and polar link but has a longer hydrophobic tail than the more abundant 6-gingerol (Item No. 11707). Like 6-gingerol, 8-gingerol activates the transient receptor potential vanilloid receptor 1 (TRPV1; EC50 = 5.0 µM), inhibits COX-2, and inhibits the growth of H. pylori in vitro.{32701,25924} 8-Gingerol also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates β-agonist-induced relaxation of airway smooth muscle.{32699,32700,32704} Oral 8-gingerol is expected to be readily absorbed and rapidly metabolized by glucuronidation and sulfation, with minimal to modest effects on cytochrome P450 isoforms.{32702,32703}  

 

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SKU: 11841 - 1 mg Category:

Description

A natural chemical that activates TRPV1 (EC50 = 5.0 µM), inhibits COX-2, and inhibits the growth of H. pylori in vitro; also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates β-agonist-induced relaxation of airway smooth muscle

Formal name: 5S-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone

Synonyms: 

Molecular weight: 322.4

CAS: 23513-08-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience

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