An adenosine A1 receptor antagonist (Ki = 10.9 nM); selective for adenosine A1 over A2 receptors (Ki = 1

8-Cyclopentyl-1,3-dimethylxanthine – 250 mg

Brand:
Cayman
CAS:
35873-49-5
Storage:
-20
UN-No:
Non-Hazardous - /

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is an adenosine A1 receptor antagonist (Ki = 10.9 nM).{48947} It is selective for adenosine A1 over A2 receptors (Ki = 1,440 nM). CPT inhibits hypoxia-induced depression of evoked synaptic potentials in rat hippocampal slices in a concentration-dependent manner.{48948} It increases secondary after-discharge duration in electrically induced seizures in rats when administered at doses of 2.5 mg/kg or higher.{48949} CPT increases the response rate under a fixed-interval schedule of stimulus-shock termination in squirrel monkeys (ED50 = 2.5 μmol/kg), indicating psychomotor stimulant effects.{48950}  

 

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Description

An adenosine A1 receptor antagonist (Ki = 10.9 nM); selective for adenosine A1 over A2 receptors (Ki = 1,440 nM); inhibits hypoxia-induced depression of evoked synaptic potentials in rat hippocampal slices; increases secondary after-discharge duration in electrically induced seizures in rats ≥2.5 mg/kg; increases the response rate under a fixed-interval schedule of stimulus-shock termination in squirrel monkeys (ED50 = 2.5 μmol/kg)

Formal name: 8-cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Synonyms:  8-Cyclopentyltheophylline|CPT|NSC 101806

Molecular weight: 248.3

CAS: 35873-49-5

Purity: ≥98%

Formulation: A crystalline solid

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