A lipophilic activator of PKA and PKG (Ka = 0.05 and 0.11 μM

8-CPT-Cyclic AMP (sodium salt) – 50 mg

Brand:
Cayman
CAS:
93882-12-3
Storage:
-20
UN-No:
Non-Hazardous - /

8-CPT-Cyclic AMP is a lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG (Ka = 0.05 and 0.11 μM, respectively).{22886} 8-CPT-cAMP inhibits cyclic GMP-specific phosphodiesterase (PDE VA), cyclic GMP-inhibited phosphodiesterase (PDE III), and cyclic AMP-specific phosphodiesterase (PDE IV) with IC50 values of 0.9, 24, and 25 μM, respectively.{22887} It has been used in studies to analyze the signal transduction pathways initiated by cyclic-AMP- and cyclic-GMP-dependent protein kinases.  

 

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SKU: 12011 - 50 mg Category:

Description

A lipophilic activator of PKA and PKG (Ka = 0.05 and 0.11 μM, respectively); inhibits PDE VA, PDE III, and PDE IV with IC50 values of 0.9, 24, and 25 μM, respectively

Formal name: 8-[(4-chlorophenyl)thio]-cyclic 3′,5′-(hydrogen phosphate)-adenosine, monosodium salt

Synonyms:  8-(p-Chlorophenylthio)-cAMP|8-CPT-cAMP

Molecular weight: 493.8

CAS: 93882-12-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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