An adenosine A2 receptor antagonist (Ki = 54 nM); selective for adenosine A2 over A1 receptors (Ki = 28 µM); reverses APEC-induced locomotor depression in mice (ED50 = 16 µg/kg

8-(3-Chlorostyryl)caffeine – 50 mg

Brand:
Cayman
CAS:
147700-11-6
Storage:
-20
UN-No:
Non-Hazardous - /

8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A2 receptor antagonist (Ki = 54 nM).{53268} It is selective for adenosine A2 over A1 receptors (Ki = 28 µM). CSC reverses locomotor depression induced by the adenosine A2A agonist APEC in mice (ED50 = 16 µg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels induced by L-DOPA (Item No. 13248) in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{53269} It also inhibits monoamine oxidase B (MAO-B; Ki = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice.{53270}  

 

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SKU: 29704 - 50 mg Category:

Description

An adenosine A2 receptor antagonist (Ki = 54 nM); selective for adenosine A2 over A1 receptors (Ki = 28 µM); reverses APEC-induced locomotor depression in mice (ED50 = 16 µg/kg, i.p.); increases locomotion in mice at 5 mg/kg; reverses L-DOPA-induced shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels in a rat model of 6-OHDA-induced Parkinson’s disease at 5 mg/kg; inhibits MAO-B (Ki = 100 nM); reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice

Formal name: 8-[(1E)-2-(3-chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

Synonyms:  CSC

Molecular weight: 330.8

CAS: 147700-11-6

Purity: ≥98%

Formulation: A solid

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