4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-3 fatty acid with a hydroxyethylamide group attached at the alpha chain.
A long-chain ω-3 fatty acid with a hydroxyethylamide group attached at the alpha chain
Formal name: N-(2-hydroxyethyl)-7Z,10Z,13Z,16Z,19Z-docosapentaenamide
Synonyms:
Molecular weight: 373.6
CAS: 351317-23-2
Purity: ≥95%
Formulation: A solution in ethanol
Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Lipids|Fatty Amides||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Fatty Acids
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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