An MCT1 and MPC inhibitor; inhibits lactate update in SiHa human cervix carcinoma cells (IC50 = 50 nM); inhibits proliferation of SiHa cells in the presence of lactate but not glucose; inhibits MPC in isolated tumor cell mitochondria; increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model at 3 mg/kg

7ACC2 – 10 mg

Brand:
Cayman
CAS:
1472624-85-3
Storage:
-20
UN-No:
Non-Hazardous - /

7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.  

 

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SKU: 23445 - 10 mg Category:

Description

An MCT1 and MPC inhibitor; inhibits lactate update in SiHa human cervix carcinoma cells (IC50 = 50 nM); inhibits proliferation of SiHa cells in the presence of lactate but not glucose; inhibits MPC in isolated tumor cell mitochondria; increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model at 3 mg/kg ,

Formal name: 7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid

Synonyms: 

Molecular weight: 309.3

CAS: 1472624-85-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Tumor Microenvironment

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