An intermediate in the synthesis of ursodeoxycholic acid by intestinal bacteria in humans; increases the bile flow rate and the concentration of bile bicarbonate in rats via venous infusion at 1.2 µmol/min per 100 g body weight; levels are decreased in rat feces in a model of adenine-induced chronic renal failure; fecal levels are also reduced in patients with liver cirrhosis or hepatocellular carcinoma

7-keto Lithocholic Acid – 10 g

Brand:
Cayman
CAS:
4651-67-6
Storage:
-20
UN-No:
Non-Hazardous - /

7-keto Lithocholic acid is an intermediate in the synthesis of the secondary bile acid ursodeoxycholic acid (Item No. 15121) by intestinal bacteria in humans.{54046,54047} It is formed from chenodeoxycholic acid (Item No. 10011286) in B. intestinalis isolated from human feces.{54046} Venous infusion of 7-keto lithocholic acid (1.2 µmol/min per 100 g body weight) increases the bile flow rate and the concentration of bile bicarbonate in rats.{54048} 7-keto Lithocholic acid levels are decreased in rat feces in a model of adenine-induced chronic renal failure.{54049} Fecal levels are also reduced in patients with liver cirrhosis or hepatocellular carcinoma.{54050}  

 

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Description

An intermediate in the synthesis of ursodeoxycholic acid by intestinal bacteria in humans; increases the bile flow rate and the concentration of bile bicarbonate in rats via venous infusion at 1.2 µmol/min per 100 g body weight; levels are decreased in rat feces in a model of adenine-induced chronic renal failure; fecal levels are also reduced in patients with liver cirrhosis or hepatocellular carcinoma

Formal name: (3α,5β)-3-hydroxy-7-oxo-cholan-24-oic acid

Synonyms:  7-keto LCA|7-Oxolithocholic Acid|NSC 226118

Molecular weight: 390.6

CAS: 4651-67-6

Purity: ≥98%

Formulation: A crystalline solid

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