A bioactive oxysterol; a major oxysterol component of oxidized LDL; produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by CYP7A1; inhibits CYP7A1 (IC50 = ~1 μM); induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state; increases ocular levels of VEGF

7-keto Cholesterol – 50 mg

Brand:
Cayman
CAS:
566-28-9
Storage:
-20
UN-No:
Non-Hazardous - /

7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL.{26766,5829} It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol (Item No. 14612) by the cytochrome P450 (CYP) isoform CYP7A1.{26764,26765,26761} 7-keto Cholesterol inhibits CYP7A1 (IC50 = ~1 μM).{26765} It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro.{39975} Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye.{39976} Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer’s disease, and age-related macular degeneration.  

 

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Description

A bioactive oxysterol; a major oxysterol component of oxidized LDL; produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by CYP7A1; inhibits CYP7A1 (IC50 = ~1 μM); induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state; increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye; levels are increased in lipid deposits in a variety of chronic diseases,

Formal name: 3β-hydroxy-cholest-5-en-7-one

Synonyms:  7-oxo Cholesterol|SC-4722|Δ5-Cholesterol-3β-ol-7-one

Molecular weight: 400.6

CAS: 566-28-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Ophthalmology||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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