An internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS

7α-hydroxy Cholesterol-d7 – 1 mg

Brand:
Cayman
CAS:
349553-94-2
Storage:
-20
UN-No:
Non-Hazardous - /

7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol (Item No. 20098) by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}  

 

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Description

An internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS,

Formal name: cholest-5-ene-25,26,26,26,27,27,27-d7-3β,7α-diol

Synonyms:  7α-hydroxycholesterol-d7

Molecular weight: 409.7

CAS: 349553-94-2

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sterol Lipids

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