An oxysterol and a precursor in the biosynthesis of CA and CDCA; formed via the oxidation of cholesterol by CYP7A1 in rat liver microsomes; increases ICAM-1

7α-hydroxy Cholesterol – 1 mg

Brand:
Cayman
CAS:
566-26-7
Storage:
-20
UN-No:
Non-Hazardous - /

7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}  

 

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Description

An oxysterol and a precursor in the biosynthesis of CA and CDCA; formed via the oxidation of cholesterol by CYP7A1 in rat liver microsomes; increases ICAM-1, VCAM-1, and E-selectin levels in HUVECs at 40 µM; increases secretion of CCL2 and MMP-9 in serum-deprived THP-1 cells at 5 µg/ml; has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet

Formal name: cholest-5-ene-3β,7α-diol

Synonyms: 

Molecular weight: 402.7

CAS: 566-26-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sterol Lipids

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