An anti-inflammatory steroid; a hydroxylated progesterone that lacks progestational and androgenic activity; inhibits phytohemagglutinin-activated T cell proliferation in vitro (IC50 = 2.9 μg/ml); inhibits TNF-α production in LPS-stimulated THP-1 cells (IC50 = 30.54 μg/ml)

6α-methyl-11β-hydroxy Progesterone – 500 mg

Brand:
Cayman
CAS:
2668-66-8
Storage:
-20
UN-No:
Non-Hazardous - /

6α-methyl-11β-hydroxy Progesterone is an anti-inflammatory steroid.{40276} It is a hydroxylated progesterone that lacks progestational and androgenic activity. It inhibits phytohemagglutinin-activated T cell proliferation in vitro with an IC50 value of 2.9 μg/ml.{40277} 6α-methyl-11β-hydroxy Progesterone also inhibits TNF-α production in LPS-stimulated THP-1 cells (IC50 = 30.54 μg/ml). Topical formulations containing 6α-methyl-11β-hydroxyprogesterone have been used to treat inflammatory ocular diseases.{40276}  

 

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Description

An anti-inflammatory steroid; a hydroxylated progesterone that lacks progestational and androgenic activity; inhibits phytohemagglutinin-activated T cell proliferation in vitro (IC50 = 2.9 μg/ml); inhibits TNF-α production in LPS-stimulated THP-1 cells (IC50 = 30.54 μg/ml)

Formal name: 11β-hydroxy-6α-methyl-pregn-4-ene-3,20-dione

Synonyms:  Medrysone|NSC 63278|Visudrisone

Molecular weight: 344.5

CAS: 2668-66-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sterol Lipids

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