A thio analog of the purine base guanine that incorporates into DNA during replication

6-Thioguanine – 1 g

Brand:
Cayman
CAS:
154-42-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}  

 

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Description

A thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity; used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors

Formal name: 2-amino-1,9-dihydro-6H-purine-6-thione

Synonyms:  6-TG|NSC 752|NSC 76504

Molecular weight: 167.2

CAS: 154-42-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|DNA Damage and Repair|DNA Intercalating Agents||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation

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