A minor

6-Shogaol – 5 mg

Brand:
Cayman
CAS:
555-66-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

6-Shogaol is a minor, bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory and anticancer properties. It is present in fresh ginger at low levels, but quantities of 6-shogaol are significantly increased in dried ginger. 6-Shogaol induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, and suppresses Toll-like receptor signaling.{29734} 6-Shogaol-rich extracts have been shown to enhance antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression in cell and animal models.{29733} It can also activate both TRPV1 and TRPA1 channels (EC50s = 0.32 and 16 µM, respectively).{25921}  

 

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SKU: 11901 - 5 mg Category:

Description

A minor, bioactive component of ginger with anti-inflammatory and anticancer properties; induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, suppresses Toll-like receptor signaling, and enhances antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression

Formal name: 1-(4-hydroxy-3-methoxyphenyl)-4-decen-3-one

Synonyms: 

Molecular weight: 276.4

CAS: 555-66-8

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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