An active metabolite of donepezil; formed through dealkylation by CYP2D6; inhibits hERG channels (IC50 = 1.5 µM)

6-O-desmethyl Donepezil – 500 µg

Brand:
Cayman
CAS:
120013-56-1
Storage:
-20
UN-No:
Non-Hazardous - /

6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}  

 

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SKU: 27175 - 500 µg Category:

Description

An active metabolite of donepezil; formed through dealkylation by CYP2D6; inhibits hERG channels (IC50 = 1.5 µM)

Formal name: 2,3-dihydro-6-hydroxy-5-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one

Synonyms: 

Molecular weight: 365.5

CAS: 120013-56-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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