A metabolite of melatonin; similar potency as melatonin for human recombinant MT1 and MT2 receptors (pKi = 9.23 and 9.93

6-hydroxy Melatonin – 1 mg

Brand:
Cayman
CAS:
2208-41-5
Storage:
-20
UN-No:
Non-Hazardous - /

6-hydroxy Melatonin is the primary active metabolite of melatonin (Item No. 14427). 6-hydroxy Melatonin acts as an agonist at the melatonin 1 (MT1) and MT2 receptors, with approximately the same potency as melatonin in a competition assay using [3H]-melatonin and human recombinant receptors (pKi = 9.23 and 9.93, respectively for MT1; 8.79 and 9.65, respectively for MT2).{34286} Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.{22956} Melatonin also has antioxidative properties, but 6-hydroxy melatonin is a better scavenger of reactive oxygen species than melatonin in rat brain homogenates.{34285,34287}  

 

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Description

A metabolite of melatonin; similar potency as melatonin for human recombinant MT1 and MT2 receptors (pKi = 9.23 and 9.93, respectively for MT1; 8.79 and 9.65, respectively for MT2); has antioxidant properties

Formal name: N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide

Synonyms: 

Molecular weight: 248.3

CAS: 2208-41-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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