An oxidized pterin that binds to one of two active sites on XO

6-Formylpterin – 10 mg

Brand:
Cayman
CAS:
712-30-1
Storage:
-20
UN-No:
Non-Hazardous - /

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}  

 

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Description

An oxidized pterin that binds to one of two active sites on XO, resulting in “hetero-substrate” inhibition at nanomolar concentrations; converted by XO to 6-carboxylpterin and H2O2, acting as an intracellular generator of H2O2 in cells expressing XO

Formal name: 2-amino-3,4-dihydro-4-oxo-6-pteridinecarboxaldehyde

Synonyms:  ​6-FP|2-Amino-6-formylpteridin-4-one|Pterin-6-aldehyde

Molecular weight: 191.1

CAS: 712-30-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Xanthine Oxidase

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