A synthetic bile acid that acts as a potent and selective agonist of FXR (EC50 = 99 nM); alters gene expression that results in protection against cholestasis as well as liver fibrosis; promotes the differentiation of adipocytes and enhances insulin signaling in mature adipocytes

6-ECDCA – 5 mg

Brand:
Cayman
CAS:
459789-99-2
Storage:
-20
UN-No:
Non-Hazardous - /

Farnesoid X receptor (FXR) is a nuclear receptor that is activated by bile acid, with chenodeoxycholic acid (CDCA) being a representative natural ligand.{20706} 6-ECDCA is a synthetic bile acid that acts as a potent and selective agonist of FXR (EC50 = 99 nM).{20705} Through FXR, it alters gene expression that results in protection against cholestasis as well as liver fibrosis.{20705,20702,20703} 6-ECDCA also, through FXR, promotes the differentiation of adipocytes and enhances insulin signaling in mature adipocytes.{20707} In ApoE-/- mice, 6-ECDCA ameliorates vascular calcification secondary to chronic kidney disease without affecting the development of atherosclerosis.{20704}  

 

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Description

A synthetic bile acid that acts as a potent and selective agonist of FXR (EC50 = 99 nM); alters gene expression that results in protection against cholestasis as well as liver fibrosis; promotes the differentiation of adipocytes and enhances insulin signaling in mature adipocytes

Formal name: (3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid

Synonyms:  INT 747|Obeticholic Acid

Molecular weight: 420.6

CAS: 459789-99-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH

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