An antiprion agent; inhibits prion formation in yeast- and mammalian-based screening assays; inhibits protein folding activity of the ribosome at 300 µM; directly competes with protein substrates for the ribosome active site and decreases the yield of refolded protein without affecting the rate of refolding; prevents progressive wing position defects in a Drosophila model of OPMD at 300-400 µM in larvae and 1-3 mM in adults

6-Aminophenanthridine – 10 mg

Brand:
Cayman
CAS:
832-68-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

6-Aminophenanthridine is an antiprion agent.{47109} It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz (Item No. 10851). 6-Aminophenanthridine (300 µM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate.{47109,47110,48081} It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 µM and in adults following dietary administration of 1-3 mM doses.{47111} 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.  

 

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SKU: 26420 - 10 mg Category:

Description

An antiprion agent; inhibits prion formation in yeast- and mammalian-based screening assays; inhibits protein folding activity of the ribosome at 300 µM; directly competes with protein substrates for the ribosome active site and decreases the yield of refolded protein without affecting the rate of refolding; prevents progressive wing position defects in a Drosophila model of OPMD at 300-400 µM in larvae and 1-3 mM in adults

Formal name: 6-phenanthridinamine

Synonyms:  6AP

Molecular weight: 194.2

CAS: 832-68-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Neuroscience|Neurodegenerative Disorders|Prion Disease

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