A well-established inhibitor of the NADP+-dependent enzyme

6-Aminonicotinamide – 1 g

Brand:
Cayman
CAS:
329-89-5
Storage:
-20
UN-No:
Non-Hazardous - /

6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM).{16482} Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).{16480,16483} 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.{16479} In addition, 6-AN causes glial neurodegeneration.{16481}  

 

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SKU: 10009315 - 1 g Category:

Description

A well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM) which interferes with glycolysis; through ATP depletion, synergizes with chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM); reduces cardiovascular oxidative injury following ischemia/reperfusion; causes glial neurodegeneration,

Formal name: 6-amino-3-pyridinecarboxamide

Synonyms:  6-AN|NSC 21206|SR 4388

Molecular weight: 137.1

CAS: 329-89-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Metabolism||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Neuroscience

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