An inhibitor of the plasmin activating enzymes streptokinase

6-Aminocaproic Acid – 100 g

Brand:
Cayman
CAS:
60-32-2
Storage:
4
UN-No:
Non-Hazardous - /

6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).{37233} It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.{37234} Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.{37235}  

 

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SKU: 23724 - 100 g Category:

Description

An inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay); selective for plasmin activating enzymes over trypsin (IC50 = >500 μM); inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner; reduces ex vivo fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg

Formal name: 6-amino-hexanoic acid

Synonyms:  EACA|NSC 212532|NSC 26154|NSC 400230|ε-Aminocaproic Acid

Molecular weight: 131.2

CAS: 60-32-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis

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