A C-7 truncated analog of LXA4 that is equiactive as LXA2 in the inhibition of LTB4-induced neutrophil chemotaxis (IC50 = 5 nM)

5(S),6(R)-7-trihydroxymethyl Heptanoate – 1 mg

Brand:
Cayman
CAS:
78606-80-1
Storage:
-20
UN-No:
De Minimis - 1230 / 3|6.1

Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid through an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP).{14813} 5(S),6(R)-7-trihydroxymethyl Heptanoate is a C-7 truncated analog of lipoxin A4 (LXA4) that is equiactive as LXA4 in the inhibition of leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis with an IC50 value of 5nM.{14813}  

 

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SKU: 10005032 - 1 mg Category:

Description

A C-7 truncated analog of LXA4 that is equiactive as LXA2 in the inhibition of LTB4-induced neutrophil chemotaxis (IC50 = 5 nM)

Formal name: 5S,6R-trihydroxy-7-heptanoic acid, methyl ester

Synonyms:  BML-111

Molecular weight: 192.2

CAS: 78606-80-1

Purity: ≥95%

Formulation: A solution in methanol

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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