Description
A natural bioactive lipid derived from AA
Formal name: 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
Synonyms:
Molecular weight: 336.5
CAS: 79056-01-2
Purity: ≥98%
Formulation: A solution in ethanol
5(S),12(S)-DiHETE – 25 µg
Brand:
Cayman
CAS:
79056-01-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3
5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid (AA; Item No. 10006607). It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA.{530} 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes.{577} It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore.{7243} 5(S),12(S)-DiHETE is an epimer of leukotriene B4 (Item No. 20110) that is weakly chemotactic for PMNL.{551}
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