A cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM); inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280 nM)

5,15-DPP – 10 mg

Brand:
Cayman
CAS:
22112-89-6
Storage:
-20
UN-No:
Non-Hazardous - /

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.{7286,11981} 5,15-DPP is a cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM).{26153} This inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280 nM), preventing nuclear translocation and DNA binding.{26153} 5,15-DPP poorly inhibits STAT1 (IC50 = 10 µM) and does not affect Grb2.{26153} It reduces IL-6-dependent STAT3 activation and consequent c-myc expression in MDA-MB-468 cells and blocks TRAIL-induced migration and invasion in A549 cells.{26153,26154} Furthermore, inhibition of JAK/STAT signaling in satellite cells via 5,15-DPP and the JAK2 inhibitor AG-490 (Item No. 10010311) has been used to stimulate muscle regeneration in a model of aging skeletal muscle deterioration.{27730}  

 

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Description

A cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM); inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280 nM), preventing nuclear translocation and DNA binding

Formal name: 5,15-diphenyl-21H,23H-porphine

Synonyms:  5,15-Diphenylporphyrin|STAT3 Inhibitor VIII

Molecular weight: 462.6

CAS: 22112-89-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Immunology & Inflammation

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