Description
5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR).{10476,11003} The 5-OxoETE receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium.{10476,11003} Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response.{11003} In addition, the protein can also be detected in tissues such as kidney and liver.{10476,11003} Cayman Chemical’s 5-OxoETE Receptor Polyclonal Antibody can be used in Western blot analysis (detection at 48 kDa) and immunocytochemistry. The high expression level of the receptor in leukocytes makes it the best positive control sample. When probing other tissue samples such as liver and kidney, membrane preparations or higher sensitivity detection systems may be required for visualization on immunoblot.
Synonyms: GPR170|OXE Receptor|OXER1|Oxoeicosanoid Receptor 1|R527|TG1019
Immunogen: Synthetic peptide from the C-terminal region of human 5-OxoETE receptor
Formulation: 500 µl of Peptide affinity-purified antibody
Isotype:
Applications: ICC and WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunocytochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways
