A polyunsaturated keto acid formed by the oxidation of 5-HETE in neutrophils by a specific dehydrogenase; stimulates the increase in cytosolic calcium levels in neutrophils (EC50 = 2 nM) and stimulates the migration and degranulation of eosinophils via a specific GPCR

5-OxoETE – 100 µg

Brand:
Cayman
CAS:
106154-18-1
Storage:
-80
UN-No:
De Minimis - 1170 / 3

5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.{2090} It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.{1434} 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.{2793,3036,10476,11003}  

 

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SKU: 34250 - 100 µg Category:

Description

A polyunsaturated keto acid formed by the oxidation of 5-HETE in neutrophils by a specific dehydrogenase; stimulates the increase in cytosolic calcium levels in neutrophils (EC50 = 2 nM) and stimulates the migration and degranulation of eosinophils via a specific GPCR

Formal name: 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid

Synonyms:  5-KETE

Molecular weight: 318.5

CAS: 106154-18-1

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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