A nucleoside analog; inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM

5-(Hydroxymethyl)-2’-deoxyuridine – 25 mg

Brand:
Cayman
CAS:
5116-24-5
Storage:
-20
UN-No:
Non-Hazardous - /

5-(Hydroxymethyl)-2’-deoxyuridine is a nucleoside analog with anticancer and antiviral activities.{38403} It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).{38403,38404} 5-(Hydroxymethyl)-2’-deoxyuridine acts synergistically with 5-fluorouracil (5-FU; Item No. 14416) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.{38405} It inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM.{38403} 5-(Hydroxymethyl)-2’-deoxyuridine is also a DNA adduct, formed in response to oxidative stress, that is found in hepatic DNA of rats treated with gamma irradiation, diethylnitrosamine, 2-acetylaminofluorene, and ciprofibrate (Item No. 18515).{38406}  

 

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Description

A nucleoside analog; inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM); acts synergistically with 5-FU against HT-29, HCT116, PANC-1, and EKVX cancer cells; inhibits HSV-1 pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM; a DNA adduct formed in response to oxidative stress,

Formal name: α-hydroxy-thymidine

Synonyms: 

Molecular weight: 258.2

CAS: 5116-24-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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