A metabolite of diclofenac formed by CYP3A4

5-hydroxy Diclofenac – 1 mg

Brand:
Cayman
CAS:
69002-84-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac (Item No. 70680) formed by the cytochrome P450 (CYP) isoform CYP3A4.{14145,38505} Diclofenac is a non-selective COX inhibitor.{1791,1286,1364} It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.{1791,1286} Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.{1364}  

 

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SKU: 23369 - 1 mg Category:

Description

A metabolite of diclofenac formed by CYP3A4

Formal name: 2-[(2,6-dichlorophenyl)amino]-5-hydroxy-benzeneacetic acid

Synonyms: 

Molecular weight: 312.2

CAS: 69002-84-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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