A pyrimadine analog that irreversibly inhibits thymidylate synthase

5-Fluorouracil – 5 g

Brand:
Cayman
CAS:
51-21-8
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

5-Fluorouracil (5-FU) is a pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-FU exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.{18418} 5-FU has been widely used to treat many gastrointestinal tract adenocarcinomas.{22957} However, its clinical application is greatly limited due to drug resistance.{22958}  

 

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Description

A pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis; widely used to treat many gastrointestinal tract adenocarcinomas

Formal name: 5-fluoro-2,4(1H,3H)-pyrimidinedione

Synonyms:  5-FU|NSC 19893|Ro 2-9757|U-8953

Molecular weight: 130.1

CAS: 51-21-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair

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