An intermediate in the generation of adenine and methionine that is produced by the decarboxylation of SAM; a potent agonist of adenosine receptors (Kis = 0.15

5′-Deoxy-5′-methylthioadenosine – 25 mg

Brand:
Cayman
CAS:
2457-80-9
Storage:
-20
UN-No:
Non-Hazardous - /

5′-Deoxy-5′-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine.{25496} This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively).{25499} At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.{25497,25496,16624,25500}  

 

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Description

An intermediate in the generation of adenine and methionine that is produced by the decarboxylation of SAM; a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively); inhibits several enzymes at higher concentrations

Formal name: 5′-S-methyl-5′-thio-adenosine

Synonyms:  5′-S-Methylthioadenosine|MTA|NSC 335422|Vitamin L2

Molecular weight: 297.3

CAS: 2457-80-9

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area

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