A chlorinated derivative of uracil; has been found in human neutrophils stimulated with PMA in vitro; has been found in inflammatory human exudate isolated from sites of superficial infection; levels are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation; levels are increased in patient-derived human atherosclerotic aortic tissue

5-Chlorouracil – 5 g

Brand:
Cayman
CAS:
1820-81-1
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil (Item No. 26088). In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.{46329} Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.{46330} 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.{46331,46332}  

 

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SKU: 27790 - 5 g Category:

Description

A chlorinated derivative of uracil; has been found in human neutrophils stimulated with PMA in vitro; has been found in inflammatory human exudate isolated from sites of superficial infection; levels are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation; levels are increased in patient-derived human atherosclerotic aortic tissue

Formal name: 5-chloro-2,4(1H,3H)-pyrimidinedione

Synonyms: 

Molecular weight: 146.5

CAS: 1820-81-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Ox Stress Reagents||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase||Research Area|Toxicology|Cell Health & Viability

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