An inhibitor of DNA methyltransferases that reduces hypermethylation associated with certain diseases

5-Azacytidine – 250 mg

Brand:
Cayman
CAS:
320-67-2
Storage:
-20
UN-No:
Non-Hazardous - /

5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.{17258} It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).{18356,18373,17257} 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.{17258}  

 

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SKU: 11164 - 250 mg Category:

Description

An inhibitor of DNA methyltransferases that reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines)

Formal name: 4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Synonyms:  5-AzaC|Antibiotic U 18496|Ladakamycin|Mylosar|NSC 102816|NSC 103-627|U 18496|WR 183027

Molecular weight: 244.2

CAS: 320-67-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation

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