An oxysterol and an oxidative metabolite of cholesterol; accumulates in MCF-7 breast cancer cells following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to LXRβ; levels are increased in rat aorta and mesenteric artery following orchidectomy; levels are increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease

5α,6α-epoxy Cholestanol – 50 mg

Brand:
Cayman
CAS:
1250-95-9
Storage:
-20
UN-No:
Non-Hazardous - /

5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ).{45076} 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}  

 

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Description

An oxysterol and an oxidative metabolite of cholesterol; accumulates in MCF-7 breast cancer cells following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to LXRβ; levels are increased in rat aorta and mesenteric artery following orchidectomy; levels are increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease

Formal name: (3β,5α,6α)-5,6-epoxy-cholestan-3-ol

Synonyms:  5α,6α-Epoxycholesterol|Cholesterol 5α,6α-epoxide|NSC 18176

Molecular weight: 402.7

CAS: 1250-95-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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