A progesterone receptor agonist and progesterone metabolite; induces ePR- or hPR-mediated gene expression in reporter assays using HepG2 cells (EC50s = 14 and 23.1 nM

5α-Dihydroprogesterone – 500 mg

Brand:
Cayman
CAS:
566-65-4
Storage:
-20
UN-No:
Non-Hazardous - /

5α-Dihydroprogesterone (5α-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{59179} It is formed from progesterone by 5α-reductase.{59180} It induces gene expression mediated by the progesterone receptor (PR) in reporter assays using HepG2 cells expressing equine PR or human PR (EC50s = 14 and 23.1 nM, respectively).{59179} 5α-DHP (0.7 mg/kg) maintains equine pregnancy in the absence of luteal progesterone. It increases proliferation of C4HD murine mammary cells when used at a concentration of 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner.{59181} 5α-DHP levels increase locally following spinal cord injury or traumatic brain injury in rats and ischemic brain injury in mice.{59180}  

 

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Description

A progesterone receptor agonist and progesterone metabolite; induces ePR- or hPR-mediated gene expression in reporter assays using HepG2 cells (EC50s = 14 and 23.1 nM, respectively); maintains equine pregnancy in the absence of luteal progesterone at 0.7 mg/kg; increases proliferation of C4HD murine mammary cells at 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner

Formal name: (5α)-pregnane-3,20-dione

Synonyms:  5α-DH PROG|5α-DHP|5α-Pregnanedione|NSC 18319

Molecular weight: 316.5

CAS: 566-65-4

Purity: ≥95%

Formulation: A solid

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