An internal standard for the quantification of 4β-hydroxy cholesterol by GC or LC-MS

4β-hydroxy Cholesterol-d7 – 1 mg

Brand:
Cayman
CAS:
1246302-80-6
Storage:
-20
UN-No:
Non-Hazardous - /

4β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 4β-hydroxy cholesterol (Item No. 19518) by GC- or LC-MS. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.  

 

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SKU: 25971 - 1 mg Category:

Description

An internal standard for the quantification of 4β-hydroxy cholesterol by GC or LC-MS

Formal name: cholest-5-ene-25,26,26,26,27,27,27-d7-3β,4β-diol

Synonyms: 

Molecular weight: 409.7

CAS: 1246302-80-6

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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