An inhibitor of the eIF4F translation initiation complex that inhibits cap-dependent translation with an IC50 value of ~4 μM; reverses tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage

4E1RCat – 1 mg

Brand:
Cayman
CAS:
328998-25-0
Storage:
-20
UN-No:
Non-Hazardous - /

4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.{31602} It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.{31602} 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.{31602}  

 

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Description

An inhibitor of the eIF4F translation initiation complex that inhibits cap-dependent translation with an IC50 value of ~4 μM; reverses tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage

Formal name: 4-​[2,​3-​dihydro-​3-​[[5-​(4-​nitrophenyl)​-​​2-​furanyl]​methylene]​-​​2-​oxo-​5-​phenyl-​1H-​​pyrrol-​1-​yl]​-​benzoic acid

Synonyms:  eIF4E/eIF4G Interaction Inhibitor II

Molecular weight: 478.5

CAS: 328998-25-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|DNA Damage and Repair||Research Area|Cancer|Multidrug Resistance

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