An allosteric agonist of α7 subunit-containing nAChRs; activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (EC50s = 17 and 128 µM

4BP-TQS – 1 mg

Brand:
Cayman
CAS:
360791-49-7
Storage:
-20
UN-No:
Non-Hazardous - /

4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s = 17 and 128 µM, respectively). It is selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM.{47589} 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.{47588} It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.  

 

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Description

An allosteric agonist of α7 subunit-containing nAChRs; activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (EC50s = 17 and 128 µM, respectively); selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM; potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes at 10 µM; activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes

Formal name: 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Synonyms: 

Molecular weight: 405.3

CAS: 360791-49-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience

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