Selectively blocks Nav1.6 channels (IC50 = 7.8 nM in Xenopus oocytes versus IC50 values of 1.3

4,9-Anhydrotetrodotoxin – 100 µg

Brand:
Cayman
CAS:
13072-89-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes).{30519,30520,23790} It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.{30519}  

 

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Description

Selectively blocks Nav1.6 channels (IC50 = 7.8 nM in Xenopus oocytes versus IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively)

Formal name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

Synonyms:  4,9-anhydro-TTX

Molecular weight: 301.3

CAS: 13072-89-4

Purity: ≥98%

Formulation: A solid or film

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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