A selective mechanism-based inhibitor of CYP2B4 and CYP2E1 at 100 µM; also used commonly as a fungicide

4-phenyl-1,2,3-Thiadiazole – 100 mg

Brand:
Cayman
CAS:
25445-77-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cytochrome P450 (CYP450) enzymes are a superfamily of oxidative catalysts important in the biosynthesis and metabolism of a wide range of endogenous molecules as well as the metabolism of xenobiotics. For example, CYP2B4 metabolizes substituted amines, CYP2E1 metabolizes various alcohols and halogenated alkenes, and CYP1A2 catalyzes the oxygenation of aromatic compounds and polycyclic hydrocarbons. 4-phenyl-1,2,3-Thiadiazole is, at 100 µM, a selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner.{15950} 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-1,2,3-thiadiazole, are also commonly used as fungicides, herbicides, and plant growth regulators.  

 

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SKU: 10011055 - 100 mg Category:

Description

A selective mechanism-based inhibitor of CYP2B4 and CYP2E1 at 100 µM; also used commonly as a fungicide, herbicide, or plant growth regulator

Formal name: 4-phenyl-1,2,3-thiadiazole

Synonyms:  NSC 111906

Molecular weight: 162.2

CAS: 25445-77-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Pesticides|Herbicides||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Plant Biology|Plant Growth Regulators||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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