A putative metabolite of DHA with antiproliferative and PPARγ agonist activity; inhibits growth of several triple negative breast cancer cell lines; binds covalently to PPARγ and activates gene transcription (EC50 = ~8-16 µM)

4-oxo Docosahexaenoic Acid – 25 µg

Brand:
Cayman
CAS:
845673-74-7
Storage:
-80
UN-No:
Non-Hazardous - /

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}  

 

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Description

A putative metabolite of DHA with antiproliferative and PPARγ agonist activity; inhibits growth of several triple negative breast cancer cell lines; binds covalently to PPARγ and activates gene transcription (EC50 = ~8-16 µM),

Formal name: 4-oxo-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid

Synonyms:  4-oxo DHA

Molecular weight: 342.5

CAS: 845673-74-7

Purity: ≥90%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Lipid Biochemistry|Fatty Acids

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