A fluorogenic substrate of β-glucosidase and β-glucocerebrosidase

4-Methylumbelliferyl-β-D-Glucopyranoside – 500 mg

Brand:
Cayman
CAS:
18997-57-4
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}  

 

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Description

A fluorogenic substrate of β-glucosidase and β-glucocerebrosidase

Formal name: 7-(β-D-glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one

Synonyms:  4-MUG|4-MU-GLU|4-MU-β-Gluc|MU-GLU

Molecular weight: 338.3

CAS: 18997-57-4

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism

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