A fluorogenic substrate for α-glucosidase; is cleaved by α-glucosidase to release the fluorescent moiety 4-MU; ex = 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3)

4-Methylumbelliferyl-α-D-Glucopyranoside – 25 mg

Brand:
Cayman
CAS:
17833-43-1
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylumbelliferyl-α-D-glucopyranoside is a fluorogenic substrate for α-glucosidase.{49104,49103} 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.{27251} 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.{49104,49103}  

 

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Description

A fluorogenic substrate for α-glucosidase; is cleaved by α-glucosidase to release the fluorescent moiety 4-MU; ex = 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively; em = 445 to 455 nm, increasing as pH decreases; has been used to quantify α-glucosidase activity in infant blood spot samples in the diagnosis of Fabry and Pompe diseases

Formal name: 7-(α-D-glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one

Synonyms:  4-Methylumbelliferyl-α-D-Glucose|4-Methylumbelliferyl-α-D-Glucoside|4-MU-α-D-Glucopyranoside

Molecular weight: 338.3

CAS: 17833-43-1

Purity: ≥95%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sphingolipids

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