A fluorogenic substrate for LAL; is cleaved by LAL to release the fluorescent moiety 4-MU; is cleaved by GALNS to release the fluorescent moiety 4-MU; ex = 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH

4-Methylumbelliferyl Palmitate – 250 mg

Brand:
Cayman
CAS:
17695-48-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cholesterol ester storage disease and Wolman disease are recessive autosomal disorders caused by a deficiency in lysosomal acid lipase (LAL), also known as cholesteryl ester hydrolase.{26282,26283} 4-Methylumbelliferyl palmitate (4-MUP) is a fluorogenic substrate for lysosomal acid lypase (LAL).{26284} 4-MUP is cleaved by LAL to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} 4-MUP may also be cleaved by other acid lipases.{26285,26286} Recent advances allow the assessment of LAL activity in very small blood volumes using 4-MUP.{26282,26283}  

 

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Description

A fluorogenic substrate for LAL; is cleaved by LAL to release the fluorescent moiety 4-MU; is cleaved by GALNS to release the fluorescent moiety 4-MU; ex = 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively; em = 445-455 nm, increasing as pH decreases,

Formal name: hexadecanoic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Synonyms:  4-MU Palmitate|4-MUP|Palmitoyl 4-Methylumbelliferone

Molecular weight: 414.6

CAS: 17695-48-6

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Lipid Biochemistry|Sterol Lipids

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