A fluorogenic substrate of neuraminidases; cleaved by neuraminidases to release the fluorescent moiety 4-MU; has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus

4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid (sodium salt) – 5 mg

Brand:
Cayman
CAS:
76204-02-9
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases.{27249} 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.{27250,27253,27252}  

 

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Description

A fluorogenic substrate of neuraminidases; cleaved by neuraminidases to release the fluorescent moiety 4-MU; has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus

Formal name: 4-methyl-2-oxo-2H-1-benzopyran-7-yl 5-(acetylamino)-3,5-dideoxy-α-neuraminic acid, monosodium salt

Synonyms:  4-MUNANA|Neu5Ac-α-4MU|Sodium 2-(4-methylumbelliferyl)-N-acetylneuraminate

Molecular weight: 489.4

CAS: 76204-02-9

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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