A fluorogenic substrate of heparin sulphamidase; cleaved by heparin sulphamidase to yield 4-MU-α-GlcNH2

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt) – 1 mg

Brand:
Cayman
CAS:
460085-45-4
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase.{39610} Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm.{39610,27251} The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251} 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.{39611}  

 

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SKU: 24931 - 1 mg Category:

Description

A fluorogenic substrate of heparin sulphamidase; cleaved by heparin sulphamidase to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU; has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders,

Formal name: 7-[[2-deoxy-2-(sulfoamino)-a-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one, monosodium salt

Synonyms:  4-MU-α-GlcNS

Molecular weight: 439.4

CAS: 460085-45-4

Purity: ≥98%

Formulation: A solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism

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