A fluorogenic substrate for chitinases and chitotriosidases; ex = 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH

4-Methylumbelliferyl-β-D-N,N’,N”-Triacetylchitotrioside – 1 mg

Brand:
Cayman
CAS:
53643-13-3
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}  

 

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SKU: 19715 - Category:

Description

A fluorogenic substrate for chitinases and chitotriosidases; ex = 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively; em = 445-455 nm, increasing as pH decreases; has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders ,

Formal name: 7-[[O-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl-(1→4)-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one

Synonyms:  MUF-triNAG

Molecular weight: 785.8

CAS: 53643-13-3

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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